Common BRCA2 variants and modification of breast and ovarian cancer risk in BRCA1 mutation carriers.

Abstract

The HH genotype of the nonconservative amino acid substitution polymorphism N372H in the BRCA2 gene was reported to be associated with a 1.3- to 1.5-fold increase in risk of both breast and ovarian cancer. As these studies concerned sporadic cancer cases, we investigated whether N372H and another common variant located in the 5'-untranslated region (203G… (More)

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@article{Hughes2005CommonBV, title={Common BRCA2 variants and modification of breast and ovarian cancer risk in BRCA1 mutation carriers.}, author={David John Hughes and Sophie M. Ginolhac and Isabelle Coupier and Marilys Corbex and Brigitte Bressac-de-Paillerets and Agn{\'e}s Chompret and Yves-Jean Bignon and Nancy Uhrhammer and Christine Lasset and Sophie Giraud and Agn{\`e}s Hardouin and Pascaline Berthet and Jean Phillipe Peyrat and Joelle Fournier and Catherine Nogu{\'e}s and Rosette Lidereau and Dani{\`e}le Muller and Jean Pierre Fricker and Michel Longy and Christine Toulas and Rosine Guimbaud and Christine M. Maugard and Sylviane Olschwang and Drakoulis Yannoukakos and Francine Durocher and A Moisan and Jacques Simard and Sylvie Mazoyer and Henry T. Lynch and Csilla Szabo and Gilbert M. Lenoir and David E. Goldgar and Dominique Stoppa-Lyonnet and Olga Sinilnikova}, journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology}, year={2005}, volume={14 1}, pages={265-7} }