Common Adult Stem Cells in the Human Breast Give Rise to Glandular and Myoepithelial Cell Lineages: A New Cell Biological Concept

@article{Boecker2002CommonAS,
  title={Common Adult Stem Cells in the Human Breast Give Rise to Glandular and Myoepithelial Cell Lineages: A New Cell Biological Concept},
  author={Werner Boecker and Roland Moll and Christopher Poremba and Roland Holland and Paul J. van Diest and Peter Dervan and Horst Buerger and D F Tang Wai and Raihanatou Ina Diallo and Burkhard Brandt and Hermann Herbst and Ansgar Schmidt and Markus M. Lerch and Igor B Buchwallow},
  journal={Laboratory Investigation},
  year={2002},
  volume={82},
  pages={737-746}
}
Breast biology and pathology are currently shaped by the two-cell concept that recognizes only glandular and myoepithelial cells. In the present study, we have visualized a previously unidentified cell population within the epithelial compartment of the breast, which displays the phenotypic characteristics of a committed stem cell.Immunofluorescence double labeling with digital image processing and Western blotting were applied to normal breast tissue as well as to noninvasive and invasive… CONTINUE READING

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