Committee Opinion No. 640: Cell-Free Dna Screening For Fetal Aneuploidy

  title={Committee Opinion No. 640: Cell-Free Dna Screening For Fetal Aneuploidy},
  journal={Obstetrics \& Gynecology},
  • Published 1 September 2015
  • Medicine
  • Obstetrics & Gynecology
ABSTRACT Noninvasive prenatal screening that uses cell-free DNA from the plasma of pregnant women offers tremendous potential as a screening method for fetal aneuploidy. A number of laboratories have validated different techniques for the use of cell-free DNA as a screening test for fetal aneuploidy. All tests have a high sensitivity and specificity for trisomy 18 and trisomy 21, regardless of which molecular technique is used. Women whose results are not reported, indeterminate, or… Expand
Contingent prenatal screening for frequent aneuploidies with cell-free fetal DNA analysis.
The results show that offering cf-DNA testing to women at high risk in traditional tests (including those with risks >1 in 50) significantly reduces false positives and, therefore, the number of invasive tests. Expand
Implications of fetoplacental mosaicism on cell‐free DNA testing: a review of a common biological phenomenon
  • F. Grati
  • Medicine
  • Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • 2016
The established knowledge of placental genetics, derived from decades of prenatal diagnostic cytogenetics, is translated into the new cfDNA testing paradigm to assist in pretest prenatal counseling, when test limits and advantages are explained, and post-test counseling,When there is discordance between a screening result and the ‘truth’. Expand
Evaluation of a novel screening method for fetal aneuploidy using cell-free DNA in maternal plasma
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Noninvasive Prenatal Testing by Cell-Free DNA: Technology, Biology, Clinical Utility, and Limitations
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Noninvasive prenatal screening for fetal sex chromosome aneuploidies
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Low Fetal Fraction of Cell-free DNA Identified by Non-invasive Prenatal DNA Testing: Possible Causes, Clinical Significance, and Tactics
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Chorionic villus sampling fails to confirm mosaic trisomy 21 fetus after positive cell‐free DNA
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