Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells.

  title={Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells.},
  author={Bart Everts and Eyal Amiel and Gerritje J. W. van der Windt and Tori C. Freitas and Robert Chott and Kevin E Yarasheski and Erika L Pearce and Edward J. Pearce},
  volume={120 7},
TLR agonists initiate a rapid activation program in dendritic cells (DCs) that requires support from metabolic and bioenergetic resources. We found previously that TLR signaling promotes aerobic glycolysis and a decline in oxidative phosphorylation (OXHPOS) and that glucose restriction prevents activation and leads to premature cell death. However, it remained unclear why the decrease in OXPHOS occurs under these circumstances. Using real-time metabolic flux analysis, in the present study, we… CONTINUE READING
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