Commissureless endocytosis is correlated with initiation of neuromuscular synaptogenesis.

@article{Wolf1998CommissurelessEI,
  title={Commissureless endocytosis is correlated with initiation of neuromuscular synaptogenesis.},
  author={Barry Wolf and Mark A. Seeger and Akira Chiba},
  journal={Development},
  year={1998},
  volume={125 19},
  pages={3853-63}
}
We show that the Commissureless (COMM) transmembrane protein is required at neuromuscular synaptogenesis. All muscles in the Drosophila embryo express COMM during the period of motoneuron-muscle interaction. It is endocytosed into muscles before synaptogenesis. In comm loss-of-function mutants, motoneuron growth cones fail to initiate synaptogenesis at target muscles. This stall phenotype is rescued by supplying wild-type COMM to the muscles. Cytoplasmically truncated COMM protein fails to… CONTINUE READING