Commercial double-indicator-dilution densitometer using heavy water: Evaluation in oleic-acid pulmonary edema

Abstract

We evaluated a commercially available, double-indicator-dilution densitometric system for the estimation of pulmonary extravascular water volume in oleic acid-induced pulmonary edema. Indocyanine green and heavy water were used as the nondiffusible and diffusible tracers, respectively. Pulmonary extravascular water volume, measured with this system, was 67% of the gravimetric value (r = 0.91), which was consistent with values obtained from the radioisotope methods. The measured volume was not influenced by changes in cardiac index over a range of 1 to 4 L · min · m2. This system is less invasive than the thermal-dye technique and has potential for repeated clinical measurements of pulmonary extravascular lung water and cardiac output.

DOI: 10.1007/BF02828285

7 Figures and Tables

Statistics

050100150'97'99'01'03'05'07'09'11'13'15'17
Citations per Year

94 Citations

Semantic Scholar estimates that this publication has 94 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Leksell1990CommercialDD, title={Commercial double-indicator-dilution densitometer using heavy water: Evaluation in oleic-acid pulmonary edema}, author={Lars G. Leksell and Mark S Schreiner and Angelina Sylvestro and Gordon R. Neufeld}, journal={Journal of Clinical Monitoring}, year={1990}, volume={6}, pages={99-106} }