Corpus ID: 40655611

Comments on "Preliminary study of high mobility group box chromosomal protein 1(HMGB1) in ankylosing spondylitis patients ".

@article{Wang2016CommentsO,
  title={Comments on "Preliminary study of high mobility group box chromosomal protein 1(HMGB1) in ankylosing spondylitis patients ".},
  author={Huaizhou Wang and Yanghua Qin},
  journal={Clinical and experimental rheumatology},
  year={2016},
  volume={34 1},
  pages={
          155
        }
}
Sirs, Chen et al. recently reported that serum HMGB1 levels were significantly higher in ankylosing spondylitis (AS) patients than healthy controls detected with a commercial ELISA kit (USCNLife Science Inc, Wuhan) (1). In this study they test the serum HMGB1 levels in 71 AS patients and 40 healthy controls, and the results were 1056.10±1033.05 ng/ml and 27.05±21.50 ng/ml, respectively. However, we wish to point out that the results may shift from the actual values. The values of HMGB1 in this… Expand
1 Citations
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References

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Preliminary study of high mobility group box chromosomal protein 1(HMGB1) in ankylosing spondylitis patients.
TLDR
HMGB1 might be a good laboratory index for the evaluation of disease activities and disease severity in AS patients and play its inflammatory role mainly via the expression of cell surface receptors TLR2, TLR4 and IL-1RAcP complex. Expand
Elevated serum levels of high mobility group box protein 1 (HMGB1) in patients with ankylosing spondylitis and its association with disease activity and quality of life
TLDR
The results suggest that HMGB1 might play an important role in the pathogenesis of AS; however, it seems not to be a good candidate for reflecting disease activity, functional abilities and the quality of life in patients with AS. Expand
High mobility group box protein-1 (HMGB-1) as a new diagnostic marker in patients with acute appendicitis
TLDR
Use of HMGB-1, especially in patients with normal WBC counts, will reduce the number of unnecessary explorations and infer that HM GB-1 might be useful in the diagnosis of AA. Expand
High-mobility group box-1, promising serological biomarker for the distinction of human WNV disease severity.
TLDR
The present study highlighted the deregulation of HMGB1 and PRDX6 serum level in WNV-infected patients and providedHMGB1 as candidate biomarker distinguishing disease severity and validated the usefulness of measuring HMBG1 for prediction of detrimental clinical outcome. Expand