Comments on "Injection lipolysis with phosphatidylcholine and deoxycholate".

@article{Salti2014CommentsO,
  title={Comments on "Injection lipolysis with phosphatidylcholine and deoxycholate".},
  author={Giovanni Salti and Raffaele Rauso},
  journal={Aesthetic surgery journal},
  year={2014},
  volume={34 4},
  pages={
          639-40
        }
}
In a previous letter to the editor, Hasengschwandtner and Gundermann1 raised the question of sodium deoxycholate's (DC) unselective action when injected subcutaneously during nonsurgical, localized fat reduction, to support their theory that phosphatidylcholine (PC) provides an indispensable adjunct to reduce DC toxicity. Although DC's efficacy on cell lysis has been scientifically2,3 and clinically4,5 proven, its unselective action5–8 has been widely debated. When assessed at various DC:PC… 

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References

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Injection lipolysis with phosphatidylcholine and deoxycholate.
TLDR
The study shows that injection lipolysis works in human fat tissue and the authors did various scientifically approved investigations and analyses.
Action of Sodium Deoxycholate on Subcutaneous Human Tissue: Local and Systemic Effects
TLDR
SD induces an inflammatory reaction in subcutaneous human fat and dose-dependent adipocyte lysis with acute pain and fibrosis and further studies will establish the best dose–result ratio, frequency of application, and long-term safety.
Phosphatidylcholine and Sodium Deoxycholate in the Treatment of Localized Fat: A Double‐Blind, Randomized Study
TLDR
Both treatments have shown moderate and equivalent efficacy in treating localized fat, with sodium deoxycholate having a slower postoperative resolution, suggesting that sodium de oxygencholate could be sufficient by itself to determine fat cell destruction and that phosphatidylcholine could be useful for obtaining a later emulsification of the fat.
Detergent Effects of Sodium Deoxycholate Are a Major Feature of an Injectable Phosphatidylcholine Formulation Used for Localized Fat Dissolution
TLDR
The phosphatidylcholine formula popularly used in subcutaneous injections for fat dissolution works primarily as a detergent causing nonspecific lysis of cell membranes, suggesting a role in eliminating unwanted adipose tissue.
Tissue‐Toxic Effects of Phosphatidylcholine/Deoxycholate after Subcutaneous Injection for Fat Dissolution in Rats and a Human Volunteer
TLDR
Injection lipolysis with PC/DC causes tissue fibrosis and necrosis of adipose and vascular tissues in rat and man, making the long-term safety of PC/ DC for nonsurgical treatment of subcutaneous fat deposits uncertain.
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TLDR
Injection lipolysis induces acute panniculitis within the treated fat tissue, associated with changes of the cytokine profile, however, their pathogenetic relevance with respect to clinical dissolving of fat needs further investigation.
Induction of fat cell necrosis in human fat tissue after treatment with phosphatidylcholine and deoxycholate
TLDR
Injections with phosphatidylcholine‐ and deoxycholate‐containing substances are used to treat localized fat accumulation and lipomas and it is believed that they induce fat cell destruction with subsequent acute panniculitis followed by a repair process of the treated fat tissue.
Phospholipids do not have lipolytic activity. A critical review
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This article re‐examines and refutes the theories of intra‐adipocyte lipolysis activated by phosphatidylcholine and by phospholipids in general, when injected into adipose tissue to reduce localized
Response to "Injection lipolysis with phosphatidylcholine and deoxycholate".
  • D. Duncan
  • Medicine
    Aesthetic surgery journal
  • 2013
In their Letter to the Editor, Dr Hasengschwandtner and Professor Gundermann of the Network Lipolysis raise some interesting points. The list of sequelae and complications provided by Network members
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