Commentary: The epigenotype--a dynamic network view of development.

  title={Commentary: The epigenotype--a dynamic network view of development.},
  author={Eva Jablonka and Ehud Lamm},
  journal={International journal of epidemiology},
  volume={41 1},
During the late 1930s and the early 1940s, a particularly productive period in his scientific life, Conrad Hal Waddington (1905–75) started to construct a new synthesis between genetics, embryology and evolution. In the 4 years between 1939 and 1943, before he became involved in military activity during the Second World War, he published two substantial books and several seminal papers, all of which were explicitly geared towards constructing of an integrated view of biology. ‘The Epigenotype… 

Epigenetics: A way to bridge the gap between biological fields.

Epigenetic inheritance, prions and evolution

This review attempts a brief overview of the periodically reviewed and debated ‘classical’ TEI phenomena and their possible implications for evolution, and focuses on a less-discussed, unique kind of protein-only epigenetic inheritance mediated by prions.

On the traces of the biosocial: Historicizing “plasticity” in contemporary epigenetics

Different traces of biosocial thinking ante litteram provide a blueprint to interrogate today’s assumptions, values, (social) ontologies, and political leanings behind similar attempts to interpret the biosocial nexus that links the authors' biology with its material, social, and cultural environments.

Investigating the evolution and development of biological complexity under the framework of epigenetics

It is argued that epigenetics itself could have emerged from complexity because of a need to self‐regulate, and hybridization complexes and hybrid organisms are explored as potential models for studying the association between epigenetics and complexity.

Conceptual Confusion: The case of Epigenetics

This network dynamics approach replaces the reductionist correspondence of molecular epigenetic modifications with concept of the epigenetic landscape, by providing a concrete and crisp correspondence.


By presenting the formal concepts of dynamical systems theory, it is shown that the “epigenetic landscape” is more than a metaphor: it has specific mathematical foundations that explain how gene regulatory networks produce multiple attractor states, the self-stabilizing patterns of gene activation across the genome that account for “Epigenetic memory”.

Epigenetics: the next big thing.

  • S. Ebrahim
  • Biology
    International journal of epidemiology
  • 2012
This issue's theme is epigenetics, and Jablonka and Lamm highlight how epigenetics now has a more specific meaning—‘the study of the mechanisms that lead to persistent developmental changes in gene activities and effects, but do not involve altered DNA base sequences from one generation to the next’.

Is epidemiology ready for epigenetics?

The revellers depicted in the painting by the Dutch artist Judith Leyster (1609–60) (Figure 1) will not have given epigenetics a passing thought. Little were they to know that indulgences, such as

Unexplored Potentials of Epigenetic Mechanisms of Plants and Animals—Theoretical Considerations

An overview of the main epigenetic mechanisms regulating gene expression is provided and it is hypothesized that animal genome can be repro-grammed by epigenetic factors from the plant protoplast.



Epigenetics comes of age in the twentyfirst century

In the nineteenth century most leading biologists believed that development and heredity were one and the same problem, but when Mendel was rediscovered at the beginning of the twentieth century, the discipline of genetics was launched and the term epigenetics had validity from the outset.

The Changing Concept of Epigenetics

Recognizing that there are epigenetic inheritance systems through which non‐DNA variations can be transmitted in cell and organismal lineages broadens the concept of heredity and challenges the widely accepted gene‐centered neo‐Darwinian version of Darwinism.

What history tells us XVII. Conrad Waddington and The nature of life

One of his last books, The nature of life, is focused on, and the main ideas of Waddington are collected, and they display the coherence of the successive statements made during his career, which casts some doubts on the true originality of many of the ideas that are currently fashionable.

Canalization of Development and the Inheritance of Acquired Characters

It is suggested that recent views on the nature of the developmental process make it easier to understand how the genotypes of evolving organisms can respond to the environment in a more co-ordinated fashion.


  • D. L. Nanney
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1958
To simplify the discussion of these two types of systems, they will be referred to as "genetic systems" and "epigenetic systems.," to emphasize the reliance of these systems on the genetic systems and to underscore their significance in developmental processes.

Microbiology, Developmental Genetics and Evolution

The major elementary components of development in higher forms, that is, cellular division, cellular differentiation and epigenetic homeostasis, are well established in microorganisms. Their

Evolution, the Extended Synthesis

In the six decades since the publication of Julian Huxley's Evolution: The Modern Synthesis, the spectacular empirical advances in the biological sciences have been accompanied by equally significant

Genome Organization and Reorganization in Evolution

  • J. Shapiro
  • Biology
    Annals of the New York Academy of Sciences
  • 2002
This article focuses on the long‐lived form of genome formatting that lies within the DNA sequence itself, and argues for a computational view of genome function as the long-term information storage organelle of each cell.

Genes, genetics, and epigenetics: a correspondence.

Over the past months, as this special issue took shape, the Editors of Science have monitored an exchange of seven letters initiated by three queries from M. Bacon. These queries concern the popular