Comment on Krysov et al , page 3101 Stress equips CLL cells to survive

CLL is characterized by the accumulation of a monoclonal population of malignant B cells with a typical CD5CD23CD20 surface Ig immunophenotype that is refractory to apoptosis. CLL is a heterogeneous disease in which, in addition to the accumulation of mutations and epigenetic changes, microenvironmental factors, in particular antigenic stimulation via the… CONTINUE READING