Comment on 'Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age'

@article{Dammann2019CommentO,
  title={Comment on 'Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age'},
  author={P. Dammann and A. Scherag and N. Zak and K. Szafranski and S. Holtze and S. Begall and H. Burda and H. Kestler and T. Hildebrandt and M. Platzer},
  journal={eLife},
  year={2019},
  volume={8}
}
Ruby et al. recently analyzed historical lifespan data on more than 3200 naked mole-rats, collected over a total observation period of about 38 years (Ruby et al., 2018). They report that mortality hazards do not seem to increase across the full range of their so-far-observed lifespan, and conclude that this defiance of Gompertz's law ‘uniquely identifies the naked mole-rat as a non-aging mammal’. Here, we explain why we believe this conclusion is premature. 

Figures and Topics from this paper

Response to comment on 'Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age'
TLDR
This work applied the left-censorship technique of Kaplan and Meier to exclude all data from the historical era in which they speculate the records to be confounded, and produced indistinguishable results from what was previously published, and thus strongly reinforced the original conclusions. Expand
Surprisingly long survival of premature conclusions about naked mole‐rat biology
TLDR
This work reviews 28 of these persistent myths about naked mole‐rat sensory abilities, ecophysiology, social behaviour, development and ageing, and where possible explains how these misunderstandings came about. Expand
The naked truth: a comprehensive clarification and classification of current 'myths' in naked mole-rat biology.
The naked mole-rat (Heterocephalus glaber) has fascinated zoologists for at least half a century. It has also generated considerable biomedical interest not only because of its extraordinaryExpand
Life expectancy, family constellation and stress in giant mole-rats (Fukomys mechowii)
TLDR
The influence of the social environment of giant mole-rats on intrafamilial aggression levels, indicators of long-term stress, and mortality, and, ultimately, mortality is analysed. Expand
Status-dependent aging rates in long-lived, social mole-rats are shaped by HPA stress axis
TLDR
The results highlight the role of the hypothalamic-pituitary-adrenal stress axis in aging, confirm already known promising targets of aging research, and suggest new ones. Expand
The HPA stress axis shapes aging rates in long-lived, social mole-rats
TLDR
This analysis suggests that the differences in life expectancy between reproductive and non-reproductive mole-rats are mainly caused by critical changes in the regulation of the hypothalamic-pituitary-adrenal stress axis, which is compatible with a considerable lifespan prolongation. Expand
Do cooperatively breeding mammals live longer? A re-appraisal
TLDR
Current data makes it impossible to rule out a causal role of subterranean living on lifespan extension in mammals, and that any future studies wanting to test for such an association should wait until more high quality longevity data is available from a wider range of permanently subterranean species. Expand
The case for extended lifespan in cooperatively breeding mammals: a re-appraisal
TLDR
Data supports a causal role of subterranean living on lifespan extension in mammals and does not find any consistent, strong evidence that cooperative breeders have longer lifespans than other mammals after having controlled for variation in body mass, mode of life and data quality. Expand
Increased longevity due to sexual activity in mole-rats is associated with transcriptional changes in the HPA stress axis
TLDR
This analysis suggests that changes in the regulation of the hypothalamic–pituitary–adrenal stress axis play a key role regarding the extended life expectancy of reproductive vs. non-reproductive mole-rats. Expand
Alternative Animal Models of Aging Research
TLDR
The specific characteristics of emerging animal models that have attracted the attention of gerontologists are summarized, an overview of the available data and resources related to these models are provided, and important insights gained from them in recent years are summarized. Expand
...
1
2
...

References

SHOWING 1-10 OF 12 REFERENCES
Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age
TLDR
Unlike all other mammals studied to date, and regardless of sex or breeding-status, the age-specific hazard of mortality did not increase with age, even at ages 25-fold past their time to reproductive maturity, in defiance of Gompertz’s law. Expand
Negligible senescence in the longest living rodent, the naked mole-rat: insights from a successfully aging species
  • R. Buffenstein
  • Biology, Medicine
  • Journal of Comparative Physiology B
  • 2007
TLDR
The naked mole-rat may be the first reported mammal showing negligible senescence over the majority of their long lifespan, and clearly physiological and biochemical processes in this species have evolved to dramatically extend healthy lifespan. Expand
Extended Longevity of Reproductives Appears to be Common in Fukomys Mole-Rats (Rodentia, Bathyergidae)
TLDR
A 20-year breeding record of Giant mole-rats Fukomys mechowii, another social bathyergid species, found that breeders indeed lived significantly longer than helpers, irrespective of social rank or other potentially confounding factors. Expand
Successful aging and sustained good health in the naked mole rat: a long-lived mammalian model for biogerontology and biomedical research.
TLDR
Surprisingly, NMRs have high levels of oxidative stress and relatively short telomeres, yet they are extremely resilient when subjected to cellular stressors and appear capable of sustaining both their genomic and protein integrity under hostile conditions. Expand
Age is just a number
The naked mole rat defies the Gompertz law and shows no sign of increased mortality risk as it gets older.
The Long-Lived Queen: Reproduction and Longevity in Female Eusocial Damaraland Mole-Rats (Fukomys damarensis)
TLDR
Assessment of mark-recapture data over 13 years in 12 colonies of Damaraland mole-rats found that queens were recaptured up to 8.5 years after initial capture, suggesting that a colony queen lives longer than her non-reproductive subordinates. Expand
Sexual activity and reproduction delay ageing in a mammal
TLDR
Here, it is shown that in a eusocial mammal, a nearly identical life history has evolved. Expand
Diversity of ageing across the tree of life
TLDR
Great variation among these species, including increasing, constant, decreasing, humped and bowed trajectories for both long- and short-lived species, challenges theoreticians to develop broader perspectives on the evolution of ageing and empiricists to study the demography of more species. Expand
Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging
TLDR
It is shown at the molecular level that livers of NMRs display progressive age-dependent changes that recapitulate typical signatures of aging despite the negligible senescence and extraordinary longevity of these rodents. Expand
Update on Slow Aging and Negligible Senescence – A Mini-Review
  • C. Finch
  • Medicine, Biology
  • Gerontology
  • 2009
This review updates developments of the concept of negligible senescence, proposed in Longevity, Senescence, and the Genome in 1990, with new information for turtles, rockfish, and the nakedExpand
...
1
2
...