Comment on "Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens" and "Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans".

@article{Currat2006CommentO,
  title={Comment on "Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens" and "Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans".},
  author={Mathias Currat and Laurent Excoffier and Wayne P Maddison and Sarah P. Otto and N. Ray and Michael C Whitlock and Sam Yeaman},
  journal={Science},
  year={2006},
  volume={313 5784},
  pages={172; author reply 172}
}
Mekel-Bobrov et al. and Evans et al. (Reports, 9 Sept. 2005, p. 1720 and p. 1717, respectively) examined sequence data from modern humans within two gene regions associated with brain development, ASPM and microcephalin, and concluded that selection of these genes must be ongoing. We show that models of human history that include both population growth and spatial structure can generate the observed patterns without selection. 
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This work was partly supported by Swiss National Science Foundation grant 3100A0-100800 to L.E. and by National Science and Engineering Research Council of Canada Discovery grants to

  • This work was partly supported by Swiss National…

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