Comment on "Large-scale sequence analysis of avian influenza isolates".

  title={Comment on "Large-scale sequence analysis of avian influenza isolates".},
  author={Edward C. Holmes and David J. Lipman and Dmitriy Zamarin and Jonathan W Yewdell},
  volume={313 5793},
  pages={1573; author reply 1573}
Obenauer et al. (Research Articles, 17 March 2006, p. 1576) reported that the influenza A virus PB1-F2 gene is evolving under strong positive selection, as documented by an extremely high ratio of the number of nonsynonymous nucleotide substitutions to the number of synonymous substitutions (dN/dS). However, we show that this observation is likely to be an artifact related to the location of PB1-F2 in the +1 reading frame of the PB1 gene. 

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10.1126/science.1131729 TECHNICALCOMMENT 1Center for Infectious Disease

R. G. Webster
Microbiol. Rev. 56, • 1992

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