Comment: Potassium Supplements vs. Potassium-Sparing Diuretics

@article{OKeeffe1991CommentPS,
  title={Comment: Potassium Supplements vs. Potassium-Sparing Diuretics},
  author={Shaun T. O’Keeffe},
  journal={Annals of Pharmacotherapy},
  year={1991},
  volume={25},
  pages={439 - 439}
}
  • S. O’Keeffe
  • Published 1 April 1991
  • Medicine
  • Annals of Pharmacotherapy
TO THE EDITOR: I wish to comment on the question of potassium supplements versus potassium-sparing diuretics in treating thiazideinduced hypokalemia (DICP 1990;24:710-1). Magnesium deficiency is also a common adverse effect of prolonged thiazide therapy. I In patients with congestive heart failure (CHF), hyperaldosteronism and digitalis therapy also promote urinary excretion of magnesium. Low serum magnesium is associated with increased arrythmias and mortality in CHF.Z Frequently magnesium… 

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Amiloride prevents thiazide-induced intracellular potassium and magnesium losses.
TLDR
It is concluded that this combination of amiloride and hydrochlorothiazide is capable of preserving the internal and external balance of potassium and magnesium on a long-term basis in the patient categories studied.
Magnesium metabolism. A review with special reference to the relationship between intracellular content and serum levels.
TLDR
Treatment of altered Mg++ status depends on the clinical setting and may include the addition of a potassium/Mg++-sparing drug to an existing diuretic regimen and Guidelines for therapy are given.
Magnesium depletion . diuretics and arrythmias Prognostic importance of the serum magnesium concentration in patients with congestive heart failure
  • J Am Coli Cardioll