Comment: Potassium Supplements vs. Potassium-Sparing Diuretics

  title={Comment: Potassium Supplements vs. Potassium-Sparing Diuretics},
  author={Shaun T. O’Keeffe},
  journal={Annals of Pharmacotherapy},
  pages={439 - 439}
  • S. O’Keeffe
  • Published 1 April 1991
  • Medicine
  • Annals of Pharmacotherapy
TO THE EDITOR: I wish to comment on the question of potassium supplements versus potassium-sparing diuretics in treating thiazideinduced hypokalemia (DICP 1990;24:710-1). Magnesium deficiency is also a common adverse effect of prolonged thiazide therapy. I In patients with congestive heart failure (CHF), hyperaldosteronism and digitalis therapy also promote urinary excretion of magnesium. Low serum magnesium is associated with increased arrythmias and mortality in CHF.Z Frequently magnesium… 


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Magnesium metabolism. A review with special reference to the relationship between intracellular content and serum levels.
Treatment of altered Mg++ status depends on the clinical setting and may include the addition of a potassium/Mg++-sparing drug to an existing diuretic regimen and Guidelines for therapy are given.
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  • J Am Coli Cardioll