Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

@article{Berer2011CommensalMA,
  title={Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination},
  author={Kerstin Berer and Marsilius Mues and Michail Koutrolos and Zakeya Al Rasbi and Marina Kleopatra Boziki and Caroline Johner and Hartmut Wekerle and Gurumoorthy Krishnamoorthy},
  journal={Nature},
  year={2011},
  volume={479},
  pages={538-541}
}
Active multiple sclerosis lesions show inflammatory changes suggestive of a combined attack by autoreactive T and B lymphocytes against brain white matter. These pathogenic immune cells derive from progenitors that are normal, innocuous components of the healthy immune repertoire but become autoaggressive upon pathological activation. The stimuli triggering this autoimmune conversion have been commonly attributed to environmental factors, in particular microbial infection. However, using the… CONTINUE READING
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