Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

@article{Berer2011CommensalMA,
  title={Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination},
  author={K. Berer and M. Mues and Michail Koutrolos and Z. A. Rasbi and M. Boziki and Caroline Johner and H. Wekerle and G. Krishnamoorthy},
  journal={Nature},
  year={2011},
  volume={479},
  pages={538-541}
}
  • K. Berer, M. Mues, +5 authors G. Krishnamoorthy
  • Published 2011
  • Biology, Medicine
  • Nature
  • Active multiple sclerosis lesions show inflammatory changes suggestive of a combined attack by autoreactive T and B lymphocytes against brain white matter. These pathogenic immune cells derive from progenitors that are normal, innocuous components of the healthy immune repertoire but become autoaggressive upon pathological activation. The stimuli triggering this autoimmune conversion have been commonly attributed to environmental factors, in particular microbial infection. However, using the… CONTINUE READING
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    Paper Mentions

    OBSERVATIONAL CLINICAL TRIAL
    Multiple sclerosis (MS) is an inflammatory disease that affects the nervous system and results in a wide range of signs and symptoms including physical and cognitive problems… Expand
    ConditionsMultiple Sclerosis
    OBSERVATIONAL CLINICAL TRIAL
    Multiple sclerosis (MS) is a chronic immune central nervous system (CNS) disease of unknown cause. Recent studies suggest that gut microbiota could be a trigger for the neuro… Expand
    ConditionsMultiple Sclerosis, Relapsing-Remitting
    InterventionOther
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