Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

  title={Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells},
  author={Yukihiro Furusawa and Yuuki Obata and Shinji Fukuda and Takaho A. Endo and Gaku Nakato and Daisuke Takahashi and Yumiko Nakanishi and Chikako Uetake and Keiko Kato and Tamotsu Kato and Masumi Takahashi and Noriko N. Fukuda and Shinnosuke Murakami and Eiji Miyauchi and Shingo Hino and Koji Atarashi and Satoshi Onawa and Yumiko Fujimura and Trevor J. Lockett and Julie M. Clarke and David L. Topping and Masaru Tomita and Shohei Hori and Osamu Ohara and Tatsuya Morita and Haruhiko Koseki and Jun Kikuchi and Kenya Honda and Koji Hase and Hiroshi Ohno},
Gut commensal microbes shape the mucosal immune system by regulating the differentiation and expansion of several types of T cell. Clostridia, a dominant class of commensal microbe, can induce colonic regulatory T (Treg) cells, which have a central role in the suppression of inflammatory and allergic responses. However, the molecular mechanisms by which commensal microbes induce colonic Treg cells have been unclear. Here we show that a large bowel microbial fermentation product, butyrate… 

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