Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

  title={Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells},
  author={Y. Furusawa and Y. Obata and S. Fukuda and Takaho A. Endo and G. Nakato and D. Takahashi and Y. Nakanishi and Chikako Uetake and K. Kato and T. Kato and Masumi Takahashi and Noriko N. Fukuda and Shinnosuke Murakami and Eiji Miyauchi and S. Hino and K. Atarashi and Satoshi Onawa and Y. Fujimura and T. Lockett and J. Clarke and D. Topping and M. Tomita and S. Hori and O. Ohara and T. Morita and H. Koseki and J. Kikuchi and K. Honda and K. Hase and H. Ohno},
  • Y. Furusawa, Y. Obata, +27 authors H. Ohno
  • Published 2013
  • Biology, Medicine
  • Nature
  • Gut commensal microbes shape the mucosal immune system by regulating the differentiation and expansion of several types of T cell. Clostridia, a dominant class of commensal microbe, can induce colonic regulatory T (Treg) cells, which have a central role in the suppression of inflammatory and allergic responses. However, the molecular mechanisms by which commensal microbes induce colonic Treg cells have been unclear. Here we show that a large bowel microbial fermentation product, butyrate… CONTINUE READING
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