Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

@article{Furusawa2013CommensalMB,
  title={Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells},
  author={Yukihiro Furusawa and Y. Obata and S. Fukuda and T. Endo and G. Nakato and D. Takahashi and Yumiko Nakanishi and Chikako Uetake and Keiko Kato and Tamotsu Kato and Masumi Takahashi and Noriko N. Fukuda and S. Murakami and E. Miyauchi and S. Hino and K. Atarashi and Satoshi Onawa and Yumiko Fujimura and T. Lockett and J. Clarke and D. Topping and M. Tomita and S. Hori and O. Ohara and T. Morita and H. Koseki and J. Kikuchi and K. Honda and K. Hase and H. Ohno},
  journal={Nature},
  year={2013},
  volume={504},
  pages={446-450}
}
Gut commensal microbes shape the mucosal immune system by regulating the differentiation and expansion of several types of T cell. Clostridia, a dominant class of commensal microbe, can induce colonic regulatory T (Treg) cells, which have a central role in the suppression of inflammatory and allergic responses. However, the molecular mechanisms by which commensal microbes induce colonic Treg cells have been unclear. Here we show that a large bowel microbial fermentation product, butyrate… Expand
Commensal microbiota regulates T cell fate decision in the gut
The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4+ T Cells
Rapid and Efficient Generation of Regulatory T Cells to Commensal Antigens in the Periphery.
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References

SHOWING 1-10 OF 52 REFERENCES
Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota
...
1
2
3
4
5
...