• DOI:10.1038/nature12721
Corpus ID: 4408815

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

@article{Furusawa2013CommensalMB,
  title={Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells},
  author={Yukihiro Furusawa and Y. Obata and S. Fukuda and T. Endo and G. Nakato and D. Takahashi and Yumiko Nakanishi and Chikako Uetake and Keiko Kato and Tamotsu Kato and Masumi Takahashi and Noriko N. Fukuda and S. Murakami and E. Miyauchi and S. Hino and K. Atarashi and Satoshi Onawa and Yumiko Fujimura and T. Lockett and J. Clarke and D. Topping and M. Tomita and S. Hori and O. Ohara and T. Morita and H. Koseki and J. Kikuchi and K. Honda and K. Hase and H. Ohno},
  journal={Nature},
  year={2013},
  volume={504},
  pages={446-450}
}

• Yukihiro Furusawa, Y. Obata, +27 authors H. Ohno
• Published 2013
• Biology, Medicine
• Nature

Gut commensal microbes shape the mucosal immune system by regulating the differentiation and expansion of several types of T cell. Clostridia, a dominant class of commensal microbe, can induce colonic regulatory T (Treg) cells, which have a central role in the suppression of inflammatory and allergic responses. However, the molecular mechanisms by which commensal microbes induce colonic Treg cells have been unclear. Here we show that a large bowel microbial fermentation product, butyrate… Expand