Commensal gut flora reduces susceptibility to experimentally induced colitis via T-cell-derived interleukin-10.

Abstract

BACKGROUND Regulatory cytokines are well known to modify experimental colitis in mice. The aim of this study was to elucidate the effect of interleukin (IL)-10 derived from different cellular sources and the effect of commensal gut flora in dextran sulfate sodium (DSS)-induced colitis in mice. METHODS Wildtype (WT) and IL-10 deficient (IL-10(-/-) ) mice… (More)
DOI: 10.1002/ibd.21587

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