Commensal bacterial endocytosis in epithelial cells is dependent on myosin light chain kinase-activated brush border fanning by interferon-γ.

@article{Wu2014CommensalBE,
  title={Commensal bacterial endocytosis in epithelial cells is dependent on myosin light chain kinase-activated brush border fanning by interferon-γ.},
  author={Li-ling Wu and Wei-Hao Peng and Wei-Ting Kuo and Ching-Ying Huang and Yen-Hsuan Ni and Kuo-Shyan Lu and Jerrold R Turner and Linda Chia-Hui Yu},
  journal={The American journal of pathology},
  year={2014},
  volume={184 8},
  pages={2260-74}
}
Abnormal bacterial adherence and internalization in enterocytes have been documented in Crohn disease, celiac disease, surgical stress, and intestinal obstruction and are associated with low-level interferon (IFN)-γ production. How commensals gain access to epithelial soma through densely packed microvilli rooted on the terminal web (TW) remains unclear. We investigated molecular and ultrastructural mechanisms of bacterial endocytosis, focusing on regulatory roles of IFN-γ and myosin light… CONTINUE READING