Commensal bacteria trigger a full dendritic cell maturation program that promotes the expansion of non‐Tr1 suppressor T cells

@article{Baba2008CommensalBT,
  title={Commensal bacteria trigger a full dendritic cell maturation program that promotes the expansion of non‐Tr1 suppressor T cells},
  author={Nobuyasu Baba and S. Samson and R. Bourdet-Sicard and M. Rubio and M. Sarfati},
  journal={Journal of Leukocyte Biology},
  year={2008},
  volume={84}
}
  • Nobuyasu Baba, S. Samson, +2 authors M. Sarfati
  • Published 2008
  • Biology, Medicine
  • Journal of Leukocyte Biology
  • Dendritic cells (DCs) orchestrate the immune response establishing immunity versus tolerance. These two opposite functions may be dictated by DC maturation status with maturity linked to immunogenicity. DCs directly interact with trillions of noninvasive intestinal bacteria in vivo, a process that contributes to gut homeostasis. We here evaluated the maturation program elicited in human DCs by direct exposure to commensal‐related bacteria (CB) in the absence of inflammatory signals. We showed… CONTINUE READING
    100 Citations
    Probiotic modulation of dendritic cell function is influenced by ageing
    • 21
    • Highly Influenced
    • PDF
    Immunity and Tolerance Induced by Intestinal Mucosal Dendritic Cells
    • J. Aliberti
    • Biology, Medicine
    • Mediators of inflammation
    • 2016
    • 11
    • PDF
    Regulation of the mucosal phenotype in dendritic cells by PPARγ: role of tissue microenvironment
    • 8

    References

    SHOWING 1-10 OF 47 REFERENCES
    Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization.
    • 433
    • Highly Influential
    • PDF
    Supernatant of Bifidobacterium breve induces dendritic cell maturation, activation, and survival through a Toll-like receptor 2 pathway.
    • 148
    CD47 Engagement Inhibits Cytokine Production and Maturation of Human Dendritic Cells1
    • 139
    • PDF
    Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation
    • 455
    A Key Role of Dendritic Cells in Probiotic Functionality
    • 261
    • PDF