Commensal bacteria trigger a full dendritic cell maturation program that promotes the expansion of non-Tr1 suppressor T cells.

@article{Baba2008CommensalBT,
  title={Commensal bacteria trigger a full dendritic cell maturation program that promotes the expansion of non-Tr1 suppressor T cells.},
  author={Nobuyasu Baba and Sandrine I. Samson and Rapha{\"e}lle Bourdet-Sicard and Manuel Rubio and Marika Sarfati},
  journal={Journal of leukocyte biology},
  year={2008},
  volume={84 2},
  pages={
          468-76
        }
}
Dendritic cells (DCs) orchestrate the immune response establishing immunity versus tolerance. These two opposite functions may be dictated by DC maturation status with maturity linked to immunogenicity. DCs directly interact with trillions of noninvasive intestinal bacteria in vivo, a process that contributes to gut homeostasis. We here evaluated the maturation program elicited in human DCs by direct exposure to commensal-related bacteria (CB) in the absence of inflammatory signals. We showed… CONTINUE READING

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