Commensal Microbiota Promote Lung Cancer Development via γδ T Cells

@article{Jin2019CommensalMP,
  title={Commensal Microbiota Promote Lung Cancer Development via γδ T Cells},
  author={Chengcheng Jin and Georgia K. Lagoudas and Chen Zhao and Susan Bullman and Tyler Jacks},
  journal={Cell},
  year={2019},
  volume={176},
  pages={998-1013.e16}
}
Lung cancer is closely associated with chronic inflammation, but the causes of inflammation and the specific immune mediators have not been fully elucidated. The lung is a mucosal tissue colonized by a diverse bacterial community, and pulmonary infections commonly present in lung cancer patients are linked to clinical outcomes. Here, we provide evidence that local microbiota provoke inflammation associated with lung adenocarcinoma by activating lung-resident γδ T cells. Germ-free or antibiotic… CONTINUE READING

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