Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease.

@article{Bloom2011CommensalBS,
  title={Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease.},
  author={Seth M. Bloom and Vinieth N Bijanki and Gerardo M. Nava and Lulu Sun and Nicole P Malvin and David L. Donermeyer and William Michael Dunne and Paul E. Allen and Thaddeus S Stappenbeck},
  journal={Cell host & microbe},
  year={2011},
  volume={9 5},
  pages={390-403}
}
The intestinal microbiota is important for induction of inflammatory bowel disease (IBD). IBD is associated with complex shifts in microbiota composition, but it is unclear whether specific bacterial subsets induce IBD and, if so, whether their proportions in the microbiota are altered during disease. Here, we fulfilled Koch's postulates in host-genotype-specific fashion using a mouse model of IBD with human-relevant disease-susceptibility mutations. From screening experiments we isolated… CONTINUE READING

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