Comm function in commissural axon guidance: cell-autonomous sorting of Robo in vivo

@article{Keleman2005CommFI,
  title={Comm function in commissural axon guidance: cell-autonomous sorting of Robo in vivo},
  author={Krystyna Keleman and Carlos Eduardo Borges Pinto Ribeiro and Barry J. Dickson},
  journal={Nature Neuroscience},
  year={2005},
  volume={8},
  pages={156-163}
}
Commissureless (Comm) controls axon guidance across the Drosophila melanogaster midline by regulating surface levels of Robo, the receptor for the midline repellent Slit. Two different models have been proposed for how Comm regulates Robo: a 'sorting' model and a 'clearance' model, both based on studies using heterologous cells in vitro. Here, we test these two models in vivo. We establish a genetic rescue assay for Comm, and use this assay to show that midline crossing does not require the… CONTINUE READING
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