Comet assay studies indicate that caffeine-mediated increase in radiation risk of embryos is due to inhibition of DNA repair.

@article{Mueller1996CometAS,
  title={Comet assay studies indicate that caffeine-mediated increase in radiation risk of embryos is due to inhibition of DNA repair.},
  author={W. U. Mueller and Tim Bauch and Andrzej Wojcik and Wilfried B{\"o}cker and C. Streffer},
  journal={Mutagenesis},
  year={1996},
  volume={11 1},
  pages={
          57-60
        }
}
It is well known that under specific conditions caffeine is able to enhance radiation risk of mammalian cells by a factor of approximately 1.5-2. Various mechanisms are discussed in the literature as possible explanations for this interaction. Inhibition of DNA repair plays a crucial role in the discussion, although direct evidence for this assumption is difficult to obtain. We used the "comet assay' in order to analyse the significance of repair inhibition by caffeine in the two-cell stage of… CONTINUE READING

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Association of protein phosphorylalion and cell cycle progression after X-irradiation of two-cell mouse embryos

  • T. Jung, Streffer.C
  • Int. J. Radial. Biol.,
  • 1991

Molecular mechanisms of DNA repair inhibition by caffeine

  • Selby.C.P, A. Sancar
  • Proc. NatlAcad. Sci. USA,
  • 1990

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