Comet-assay in combination with PNA-FISH detects mutagen-induced DNA damage and specific repeat sequences in the damaged DNA of transformed cells.

Abstract

The Comet-assay was applied to three transformed cell lines (HT1080, CCRF-CEM line and CHO) which were treated with the cytostatics bleomycin (BLM) or mitomycin C (MMC). In addition, PNA probes for the telomere repeat (TTAGGG)(n) were used for detection of telomeric DNA sequences in the damaged DNA. Data were compared with previously obtained results from… (More)

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Cite this paper

@article{Hovhannisyan2005CometassayIC, title={Comet-assay in combination with PNA-FISH detects mutagen-induced DNA damage and specific repeat sequences in the damaged DNA of transformed cells.}, author={Grigori Hovhannisyan and Alexander Rapp and Rouben M Arutyunyan and Karl Otto Greulich and Erich Gebhart}, journal={International journal of molecular medicine}, year={2005}, volume={15 3}, pages={437-42} }