Comedone formation: etiology, clinical presentation, and treatment.

  title={Comedone formation: etiology, clinical presentation, and treatment.},
  author={William James Cunliffe and Diana B Holland and Alison Jeremy},
  journal={Clinics in dermatology},
  volume={22 5},
An important feature in the etiology of acne is the presence of pilosebaceous ductal hypercornification, which can be seen histologically as microcomedones (Fig 1) and clinically as blackheads, whiteheads, and other forms of comedones, such as macrocomedones. There is a significant correlation between the severity of acne and the number and size of microcomedones (follicular casts), the presence of which is a measure of comedogenesis. This correlation can be demonstrated by skin surface biopsy… CONTINUE READING

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