Combretastatin A-4 phosphate suppresses development and induces regression of choroidal neovascularization.

PURPOSE Combretastatin A-4 (CA-4) is a naturally occurring agent that binds tubulin and causes necrosis and shrinkage of tumors by damaging their blood vessels. In this study the effect of a CA-4 prodrug, combretastatin A-4-phosphate (CA-4-P), was tested in two models of ocular neovascularization. METHODS The effect of CA-4-P was quantitatively assessed… CONTINUE READING