Combining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analogs as small molecule inhibitors of Abeta oligomer-induced cytotoxicity.

@article{Hong2007CombiningTR,
  title={Combining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analogs as small molecule inhibitors of Abeta oligomer-induced cytotoxicity.},
  author={H Hong and Izumi Maezawa and Nianhuan Yao and Bailing Xu and Ruben Diaz-Avalos and Sandeep Rana and Duy H Hua and Russell C. H. Cheng and Kit Sang Lam and Lee-way Jin},
  journal={Brain research},
  year={2007},
  volume={1130 1},
  pages={223-34}
}
The discovery of small molecule inhibitors of cytotoxicity induced by amyloid-beta (Abeta) oligomers, either applied extracellularly or accumulated intraneuronally, is an important goal of drug development for Alzheimer's disease (AD), but has been limited by the lack of efficient screening methods. Here we describe our approach using two cell-based methods. The first method takes advantage of the unique ability of extracellularly applied Abeta oligomers to rapidly induce the exocytosis of… CONTINUE READING

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