Combining the antigen processing components TAP and Tapasin elicits enhanced tumor-free survival.

  title={Combining the antigen processing components TAP and Tapasin elicits enhanced tumor-free survival.},
  author={Yuanmei Lou and G. Reddy Basha and Robyn P. Seipp and Bing Cai and Susan S. Chen and Alexander R Moise and Andrew P Jeffries and Ray S Gopaul and Timothy Z. Vitalis and Wilfred A Jefferies},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={14 5},
PURPOSE Tpn is a member of the MHC class I loading complex and functions to bridge the TAP peptide transporter to MHC class I molecules. Metastatic human carcinomas often express low levels of the antigen-processing components Tapasin and TAP and display few functional surface MHC class I molecules. As a result, carcinomas are unrecognizable by effector CTLs. The aim of this study is to examine if Tapasin (Tpn) plays a critical role in the escape of tumors from immunologic recognition… CONTINUE READING


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