Combining solution wide-angle X-ray scattering and crystallography: determination of molecular envelope and heavy-atom sites.

Solving the phase problem remains central to crystallographic structure determination. A six-dimensional search method of molecular replacement (FSEARCH) can be used to locate a low-resolution molecular envelope determined from small-angle X-ray scattering (SAXS) within the crystallographic unit cell. This method has now been applied using the higher… CONTINUE READING