Combining peptide recognition specificity and context information for the prediction of the 14-3-3-mediated interactome in S. cerevisiae and H. sapiens.

@article{Panni2011CombiningPR,
  title={Combining peptide recognition specificity and context information for the prediction of the 14-3-3-mediated interactome in S. cerevisiae and H. sapiens.},
  author={S. Panni and Luisa Montecchi-Palazzi and Lars Kiemer and Andrea Cabibbo and Serena Paoluzi and Elena Santonico and Christiane Landgraf and Rudolph Volkmer-Engert and Angela Bachi and Luisa Castagnoli and Gianni Cesareni},
  journal={Proteomics},
  year={2011},
  volume={11 1},
  pages={
          128-43
        }
}
Large-scale interaction studies contribute the largest fraction of protein interactions information in databases. However, co-purification of non-specific or indirect ligands, often results in data sets that are affected by a considerable number of false positives. For the fraction of interactions mediated by short linear peptides, we present here a combined experimental and computational strategy for ranking the reliability of the inferred partners. We apply this strategy to the family of 14-3… CONTINUE READING
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