Combining optogenetic stimulation and fMRI to validate a multivariate dynamical systems model for estimating causal brain interactions

@article{Ryali2016CombiningOS,
  title={Combining optogenetic stimulation and fMRI to validate a multivariate dynamical systems model for estimating causal brain interactions},
  author={Srikanth Ryali and Yen-Yu Ian Shih and Tianwen Chen and John Kochalka and Daniel L. Albaugh and Zhongnan Fang and Kaustubh Supekar and Jin Hyung Lee and Vinod Menon},
  journal={NeuroImage},
  year={2016},
  volume={132},
  pages={398-405}
}
State-space multivariate dynamical systems (MDS) (Ryali et al. 2011) and other causal estimation models are being increasingly used to identify directed functional interactions between brain regions. However, the validity and accuracy of such methods are poorly understood. Performance evaluation based on computer simulations of small artificial causal networks can address this problem to some extent, but they often involve simplifying assumptions that reduce biological validity of the resulting… CONTINUE READING
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