Combining multiplex reverse transcription-PCR and a diagnostic microarray to detect and differentiate enterovirus 71 and coxsackievirus A16.

@article{Chen2006CombiningMR,
  title={Combining multiplex reverse transcription-PCR and a diagnostic microarray to detect and differentiate enterovirus 71 and coxsackievirus A16.},
  author={T H Chen and Guang-Wu Chen and Chao A. Hsiung and J Y Yang and Shin-Ru Shih and Yiu-Kay Lai and J P Juang},
  journal={Journal of clinical microbiology},
  year={2006},
  volume={44 6},
  pages={2212-9}
}
Cluster A enteroviruses, including enterovirus 71 (EV71) and coxsackievirus A16 (CA16), are known to cause hand-foot-and-mouth disease (HFMD). Despite the close genetic relationship between these two viruses, EV71 is generally known to be a more perpetuating pathogen involved in severe clinical manifestations and deaths. While the serotyping of enteroviruses is mostly done by conventional immunological methods, many clinical isolates remain unclassifiable due to the limited number of antibodies… CONTINUE READING

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