Combining metabolomics and network analysis to improve tacrolimus production in Streptomyces tsukubaensis using different exogenous feedings

@article{Wang2017CombiningMA,
  title={Combining metabolomics and network analysis to improve tacrolimus production in Streptomyces tsukubaensis using different exogenous feedings},
  author={Cheng Wang and Jiao Liu and Huanhuan Liu and Shaoxiong Liang and Jianping Wen},
  journal={Journal of Industrial Microbiology & Biotechnology},
  year={2017},
  volume={44},
  pages={1527-1540}
}
Tacrolimus is widely used as an immunosuppressant in the treatment of various autoimmune diseases. However, the low fermentation yield of tacrolimus has thus far restricted its industrial applications. To solve this problem, the time-series response mechanisms of the intracellular metabolism that were highly correlated with tacrolimus biosynthesis were investigated using different exogenous feeding strategies in S. tsukubaensis. The metabolomic datasets, which contained 93 metabolites, were… CONTINUE READING
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