Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension.

@article{Hoeper2006CombiningII,
  title={Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension.},
  author={Marius M Hoeper and Hanno H. Leuchte and Michael Halank and Heinrike Wilkens and Franz Joachim Meyer and H J Seyfarth and Roland Wensel and F Ripken and Hinrich Bremer and Stefan Kluge and Gert Hoeffken and J{\"u}rgen Behr},
  journal={The European respiratory journal},
  year={2006},
  volume={28 4},
  pages={691-4}
}
Addition of inhaled iloprost to bosentan may have beneficial effects in patients with idiopathic pulmonary arterial hypertension (IPAH). A multicentre, open, randomised, controlled trial was performed to assess the safety and efficacy of inhaled iloprost in patients with IPAH who had already been treated with bosentan. The trial was terminated early after a futility analysis predicted failure with respect to the predetermined sample size. At that time, 40 patients were randomised to receive… CONTINUE READING

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