Combining infliximab with 6-mercaptopurine/azathioprine for fistula therapy in Crohn's disease

OBJECTIVES:Fistulas occur in about one third of patients with Crohn's disease and rarely heal spontaneously. Conventional medical and surgical therapy often fails. The anti-TNF-α antibody infliximab offers a novel therapeutic option. By this approach, closure of fistulas was reported in 45% of cases. However, after discontinuation of therapy, most fistulas… CONTINUE READING