Combining inference from evolution and geometric probability in protein structure evaluation.

@article{Mihalek2003CombiningIF,
  title={Combining inference from evolution and geometric probability in protein structure evaluation.},
  author={I. Mihalek and I. Res and Hui Yao and Olivier Lichtarge},
  journal={Journal of molecular biology},
  year={2003},
  volume={331 1},
  pages={263-79}
}
Starting from the hypothesis that evolutionarily important residues form a spatially limited cluster in a protein's native fold, we discuss the possibility of detecting a non-native structure based on the absence of such clustering. The relevant residues are determined using the Evolutionary Trace method. We propose a quantity to measure clustering of the… CONTINUE READING