Combining individual patient data and aggregate data in mixed treatment comparison meta-analysis: Individual patient data may be beneficial if only for a subset of trials.

@article{Donegan2013CombiningIP,
  title={Combining individual patient data and aggregate data in mixed treatment comparison meta-analysis: Individual patient data may be beneficial if only for a subset of trials.},
  author={Sarah Donegan and Paula Williamson and Umberto D'Alessandro and Paul Garner and Catrin Tudur Smith},
  journal={Statistics in medicine},
  year={2013},
  volume={32 6},
  pages={914-30}
}
BACKGROUND Individual patient data (IPD) meta-analysis is the gold standard. Aggregate data (AD) and IPD can be combined using conventional pairwise meta-analysis when IPD cannot be obtained for all relevant studies. We extend the methodology to combine IPD and AD in a mixed treatment comparison (MTC) meta-analysis. METHODS The proposed random-effects MTC models combine IPD and AD for a dichotomous outcome. We study the benefits of acquiring IPD for a subset of trials when assessing the… CONTINUE READING
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