Combining extremely concordant sibpairs with extremely discordant sibpairs provides a cost effective way to linkage analysis of quantitative trait loci.

@article{Gu1996CombiningEC,
  title={Combining extremely concordant sibpairs with extremely discordant sibpairs provides a cost effective way to linkage analysis of quantitative trait loci.},
  author={Chi Charles Gu and Alexandre A. Todorov and S. D. Thirumala Rao},
  journal={Genetic epidemiology},
  year={1996},
  volume={13 6},
  pages={
          513-33
        }
}
Extremely discordant (ED) sibpairs have been shown to be very powerful for linkage analysis of human quantitative traits [Risch and Zhang (1995) Science 268: 1584-1589]. In many cases, the extremely concordant (EC) sibpairs collected in the process of screening for ED sibpairs carry valuable information for linkage. Therefore, it seems justifiable to investigate the advantages of genotyping and to include them with the ED sibpairs for linkage analysis. Herein we explore the distributions of EC… CONTINUE READING
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