Combining experimental and mathematical modeling to reveal mechanisms of macrophage-dependent left ventricular remodeling

@inproceedings{Jin2010CombiningEA,
  title={Combining experimental and mathematical modeling to reveal mechanisms of macrophage-dependent left ventricular remodeling},
  author={Yufang Jin and Hai-Chao Han and Jamie Berger and Qiuxia Dai and Merry L Lindsey},
  booktitle={BMC Systems Biology},
  year={2010}
}
Progressive remodeling of the left ventricle (LV) following myocardial infarction (MI) can lead to congestive heart failure, but the underlying initiation factors remain poorly defined. The objective of this study, accordingly, was to determine the key factors and elucidate the regulatory mechanisms of LV remodeling using integrated computational and experimental approaches. By examining the extracellular matrix (ECM) gene expression and plasma analyte levels in C57/BL6J mice LV post-MI and ECM… CONTINUE READING

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