Combining evolutionary information and neural networks to predict protein secondary structure

@article{Rost1994CombiningEI,
  title={Combining evolutionary information and neural networks to predict protein secondary structure},
  author={B. Rost and C. Sander},
  journal={Proteins: Structure},
  year={1994},
  volume={19}
}
Using evolutionary information contained in multiple sequence alignments as input to neural networks, secondary structure can be predicted at significantly increased accuracy. Here, we extend our previous three‐level system of neural networks by using additional input information derived from multiple alignments. Using a position‐specific conservation weight as part of the input increases performance. Using the number of insertions and deletions reduces the tendency for overprediction and… Expand
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