Combining autologous dendritic cell therapy with CD3 antibodies promotes regulatory T cells and permanent islet allograft acceptance.

@article{Baas2014CombiningAD,
  title={Combining autologous dendritic cell therapy with CD3 antibodies promotes regulatory T cells and permanent islet allograft acceptance.},
  author={Marije C. Baas and Christian Kuhn and Fabrice Valette and Claire Mangez and Mercedes Segovia Duarte and Maria T. Hill and Alix Besançon and Lucienne Chatenoud and Maria-Cristina Cuturi and Sylvaine You},
  journal={Journal of immunology},
  year={2014},
  volume={193 9},
  pages={
          4696-703
        }
}
Cell therapy and the use of mAbs that interfere with T cell effector functions constitute promising approaches for the control of allograft rejection. In the current study, we investigated a novel approach combining administration of autologous tolerogenic dendritic cells with short-term treatment with CD3-specific Abs. Permanent acceptance of pancreatic islet allografts was achieved in mice treated with the combination therapy the day before transplantation but not in recipients treated with… CONTINUE READING
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VIEW 1 EXCERPT
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References

Publications referenced by this paper.
SHOWING 1-10 OF 47 REFERENCES

Cell therapy with autologous tolerogenic dendritic cells induces allograft tolerance through interferon-gamma and epstein-barr virus-induced gene 3.

  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2011
VIEW 13 EXCERPTS
HIGHLY INFLUENTIAL

Autologous dendritic cells prolong allograft survival through Tmem176b-dependent antigen cross-presentation.

  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2014
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Induction of allograft tolerance by monoclonal CD3 antibodies: a matter of timing.

  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2012
VIEW 5 EXCERPTS

Prolongation of heart allograft survival by immature dendritic cells generated from recipient type bone marrow progenitors.

  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2005
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Delayed Anti-CD3 Therapy Results in Depletion of Alloreactive T Cells and the Dominance of Foxp3+CD4+ Graft Infiltrating Cells

  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2013
VIEW 2 EXCERPTS