Combining atomic force and fluorescence microscopy for analysis of quantum-dot labeled protein-DNA complexes.

@article{Ebenstein2009CombiningAF,
  title={Combining atomic force and fluorescence microscopy for analysis of quantum-dot labeled protein-DNA complexes.},
  author={Yuval Ebenstein and Natalie R Gassman and Soohong Kim and Shimon Weiss},
  journal={Journal of molecular recognition : JMR},
  year={2009},
  volume={22 5},
  pages={397-402}
}
Atomic force microscopy (AFM) and fluorescence microscopy are widely used for the study of protein-DNA interactions. While AFM excels in its ability to elucidate structural detail and spatial arrangement, it lacks the ability to distinguish between similarly sized objects in a complex system. This information is readily accessible to optical imaging techniques via site-specific fluorescent labels, which enable the direct detection and identification of multiple components simultaneously. Here… CONTINUE READING

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