Combining animal personalities with transcriptomics resolves individual variation within a wild‐type zebrafish population and identifies underpinning molecular differences in brain function

@article{Rey2013CombiningAP,
  title={Combining animal personalities with transcriptomics resolves individual variation within a wild‐type zebrafish population and identifies underpinning molecular differences in brain function},
  author={Sonia Rey and Sebasti{\'a}n Bolta{\~n}a and Reynaldo Vargas and Nerea Roher and Simon Mackenzie},
  journal={Molecular Ecology},
  year={2013},
  volume={22}
}
Resolving phenotype variation within a population in response to environmental perturbation is central to understanding biological adaptation. Relating meaningful adaptive changes at the level of the transcriptome requires the identification of processes that have a functional significance for the individual. This remains a major objective towards understanding the complex interactions between environmental demand and an individual's capacity to respond to such demands. The interpretation of… 
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References

SHOWING 1-10 OF 85 REFERENCES
Variation in tissue-specific gene expression among natural populations
TLDR
Examining the expression of a selected suite of 192 metabolic genes in brain, heart and liver in three populations of the teleost fish Fundulus heteroclitus indicates that many tissue-specific differences in gene expression are unique to one population and thus are unlikely to contribute to fundamental differences between tissue types.
Variation within and among species in gene expression: raw material for evolution
TLDR
Evolutionary analyses of gene expression reviewed here provide unique insights into partitioning of regulatory variation in nature, including the tendency to assume a linear relationship between expression divergence and species divergence and failure to test explicit hypotheses that involve the ecological context of evolutionary divergence.
Variance of Gene Expression Identifies Altered Network Constraints in Neurological Disease
TLDR
An innovative approach to the analysis of gene expression data is described, one that identifies differences in expression variance between groups as an informative metric of the group phenotype, and finds that genes with different expression variance profiles are not randomly distributed across cell signaling networks.
The biological importance of measuring individual variation
TLDR
It is found that among different groups of individuals, the expression of mRNA from different metabolic pathways explains substrate-specific metabolism, and there are surprisingly strong positive and negative correlations among metabolic genes, both within and between pathways.
Behavioral syndromes and the evolution of correlated behavior in zebrafish
TLDR
Evidence of an activity syndrome is found in zebrafish, as if underlying metabolic costs influence variation in multiple forms of behavior, and a relationship between boldness and aggression was also apparent but depended both on strain and which specific behavior patterns were identified as measures of "boldness.
Stochastic epigenetic variation as a driving force of development, evolutionary adaptation, and disease
Neo-Darwinian evolutionary theory is based on exquisite selection of phenotypes caused by small genetic variations, which is the basis of quantitative trait contribution to phenotype and disease.
The importance of wild populations in studies of animal temperament
TLDR
This review highlights potential problems that arise from using captive animals to elucidate the ecological and evolutionary functions of temperament in wild populations, and stresses the need for measurements of repeatability and heritability, and the importance of biological and ecological validation of temperament tests in wild animals.
The Quantitative Genetic Architecture of the Bold-Shy Continuum in Zebrafish, Danio rerio
TLDR
The quantitative genetic architecture of the bold-shy continuum indicates that the multivariate behavioral phenotype characteristic of a “bold” personality type may be a result of correlated evolution via underlying genetic correlations.
Cis-acting variation in the expression of a high proportion of genes in human brain
TLDR
It is suggested that cis-acting variation in gene expression commonly occurs in native tissue and hence empirical support is provided for the hypothesis that this is potentially an important mechanism underlying human phenotypic diversity.
Dynamic Zebrafish Interactome Reveals Transcriptional Mechanisms of Dioxin Toxicity
TLDR
The hypothesis that dioxin, best known in fish as a potent cardioteratogen, has many other targets is suggested, including calcium and iron metabolism, embryonic morphogenesis including neuronal and retinal development, a variety of mitochondria-related functions, and generalized stress response.
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