Combining angiotensin II blockade and renin receptor inhibition results in enhanced antifibrotic effect in experimental nephritis.

@article{Zhang2011CombiningAI,
  title={Combining angiotensin II blockade and renin receptor inhibition results in enhanced antifibrotic effect in experimental nephritis.},
  author={Jiandong Zhang and Chunyan Gu and N. Noble and Wayne A. Border and Yufeng Huang},
  journal={American journal of physiology. Renal physiology},
  year={2011},
  volume={301 4},
  pages={F723-32}
}
The limited antifibrotic effect of therapeutic angiotensin blockade, the fact that angiotensin blockade dramatically elevates renin levels, and recent evidence that renin has an angiotensin-independent, receptor-mediated profibrotic action led us to hypothesize that combining renin receptor inhibition and ANG II blockade would increase the antifibrotic effect of angiotensin blockade alone. Using cultured nephritic glomeruli from rats with anti-Thy-1-induced glomerulonephritis, the maximally… CONTINUE READING
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