Combining Opioid and Adrenergic Mechanisms for Chronic Pain

@article{Smith2014CombiningOA,
  title={Combining Opioid and Adrenergic Mechanisms for Chronic Pain},
  author={H. Smith and R. Raffa and J. Pergolizzi and R. Taylor and R. Tallarida},
  journal={Postgraduate Medicine},
  year={2014},
  volume={126},
  pages={114 - 98}
}
  • H. Smith, R. Raffa, +2 authors R. Tallarida
  • Published 2014
  • Medicine
  • Postgraduate Medicine
  • Abstract Chronic pain is a highly prevalent medical problem in the United States. Although opioids and serotonin-norepinephrine reuptake inhibitors (SNRIs) have demonstrated efficacy for relief of chronic pain, each has risks of adverse events in patients. Because of the risk of opioid abuse and addiction, combinations reducing opioid requirements are particularly valuable. Opioid and SNRI agents relieve pain by different pathways; concurrent use of each agent separately offers many potential… CONTINUE READING
    Designing safer analgesics: a focus on μ-opioid receptor pathways
    • 18
    Correlation of ADRB1 rs1801253 Polymorphism with Analgesic Effect of Fentanyl After Cancer Surgeries
    • 6
    • PDF

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 147 REFERENCES
    Tapentadol in Pain Management
    • 84
    Opioid metabolism.
    • 278
    • PDF
    Opioids and neuropathic pain.
    • 64
    • PDF