Combining Incretin-Based Therapies With Insulin

  title={Combining Incretin-Based Therapies With Insulin},
  author={Jiten Vora},
  booktitle={Diabetes care},
What is the rationale for adding incretin-based therapies to insulin? The combination of the incretin-based therapies, i.e., the dipeptidyl peptidase (DPP)-4 inhibitors and glucagon-like peptide (GLP)-1 receptor agonists (GLP-1RAs), with basal insulin has, in theory, logical appeal. While basal insulin primarily improves fasting plasma glucose (FPG) control, the glucose-dependent effect of incretins will additionally benefit postprandial plasma glucose (PPG) control. This should enable improved… CONTINUE READING