Combining Human Epigenetics and Sleep Studies in Caenorhabditis elegans: A Cross-Species Approach for Finding Conserved Genes Regulating Sleep.

@article{Huang2017CombiningHE,
  title={Combining Human Epigenetics and Sleep Studies in Caenorhabditis elegans: A Cross-Species Approach for Finding Conserved Genes Regulating Sleep.},
  author={Huiyan Huang and Yong Lian Zhu and Melissa N. Eliot and Valerie S. Knopik and John E. McGeary and Mary A. Carskadon and Anne C Hart},
  journal={Sleep},
  year={2017},
  volume={40 6}
}
Study Objectives We aimed to test a combined approach to identify conserved genes regulating sleep and to explore the association between DNA methylation and sleep length. Methods We identified candidate genes associated with shorter versus longer sleep duration in college students based on DNA methylation using Illumina Infinium HumanMethylation450 BeadChip arrays. Orthologous genes in Caenorhabditis elegans were identified, and we examined whether their loss of function affected C. elegans… CONTINUE READING
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