Combined water-soluble carriers for coprecipitates of tolbutamide.

  title={Combined water-soluble carriers for coprecipitates of tolbutamide.},
  author={M J Miralles and J W McGinty and Anthony E. Martin},
  journal={Journal of pharmaceutical sciences},
  volume={71 3},
A study was conducted on the influence of single and combined carriers on the dissolution rate of tolbutamide from its coprecipitates. All of the water-soluble carriers investigated enhanced the dissolution rate of tolbutamide, but the combination of 40% polyethylene glycol 6000--60% dextrose as the carrier for a 1:1 coprecipitate yielded the most rapid… CONTINUE READING