Combined use of toll-like receptor agonists and prostaglandin E(2) in the FastDC model: rapid generation of human monocyte-derived dendritic cells capable of migration and IL-12p70 production.

@article{Dauer2008CombinedUO,
  title={Combined use of toll-like receptor agonists and prostaglandin E(2) in the FastDC model: rapid generation of human monocyte-derived dendritic cells capable of migration and IL-12p70 production.},
  author={Marc Dauer and Veronique Lam and Hannah Arnold and Jana Junkmann and Rosemarie Kiefl and Christian R. K. D. Bauer and Max Schnurr and Stefan C. Endres and Andreas Eigler},
  journal={Journal of immunological methods},
  year={2008},
  volume={337 2},
  pages={97-105}
}
Phenotypical maturation, IL-12p70 production and migration upon chemokine receptor CCR7 ligation are currently proposed as requirements for the use of human monocyte-derived dendritic cells (DC) in antitumoral vaccination. We have previously described a short-term protocol for DC generation from monocytes including stimulation with TNF-alpha, IL-1beta and PGE(2) (FastDC). These "conventional" FastDC are mature, migrate in response to CCR7 ligation and effectively stimulate autologeous T cells… CONTINUE READING
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